Announcement:

A recent study by a team at Unilever has demonstrated the predictive power of NAM approaches for the comprehensive safety assessment of compounds by combining in vitro models with advanced computational techniques. They used the aProximate™ proximal tubule cell model to assess potential nephrotoxicity and renal transport kinetics.

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Resources

Scientific Publications

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Making safety decisions for a sunscreen active ingredient using next-generation risk assessment: Benzophenone-4 case study

Unravelling genotype-phenotype correlations in Stargardt disease using patient-derived retinal organoids

Comparison of the Impact of VRP-034 and Polymyxin B upon markers of Kidney Injury in Human Proximal Tubule Monolayers In Vitro

Keith Pye, Elena Tasinato, Siannah Shuttleworth, Claire Devlin and Colin Brown

Posters

Generation of a physiologically relevant in vitro model of autosomal dominant Retinitis Pigmentosa caused by RHO-P23H mutation using 3D retinal organoids

Utilization of high – content imaging for the study of lung fibrosis

High content imaging (HCI) assays enable the study of the fibrotic processes: fibroblast – to – myofibroblast transition (FMT) and epithelial – to – mesenchymal transition (EMT)

White Papers

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Use of the aProximate Proximal Tubule Cell model for the evaluation of safety and renal accumulation of radioconjugates and large molecules

Colin Brown

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Fact Sheets

Ciliary beat frequency analysis assay for lung small airway epithelium cells (SAEC)

iPSC-derived Retinal Pigment Epithelium (RPE)

iPSC-derived Retinal Organoids (RO)

Press releases

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Newcells Biotech

Newcells Biotech strengthens executive and US team with key appointments

Scientific eBooks and Protocols

Lung models eBook

aProximate™ Assay-Ready Plates User Guide Cover.

aProximate™ Assay-Ready Plates (Human, 96-well) User Guide

The front cover of the retinal organoid ebook

Retinal Organoids eBook

Q&A with our scientists

Dr Fiona Leslie

Meet the scientists: Dr Fiona Leslie, the scientist behind the development of the advanced FMT assay

Meet the scientists: Anusha Gupta, the scientist behind the development of the CBF assay

Dr Colin Brown face inside cells

The inside story of the development of Newcells’ MPS flow model: Scientific chat with Dr Colin Brown

Videos and Webinars

In Vitro Retinal Models: A New Era in Drug Discovery & Gene Therapy

Harnessing Advanced In Vitro Lung Assays for Compound Screening

The Real Impact of In Vitro Kidney Models: Better Data, Safer Drugs

Case Studies

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Analysis of the effect of a compound on retinal microtissue composition

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Development of a human in vitro model for retinitis pigmentosa

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Assessing the validity of a nephron model for a metabolic disease study

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DDI study on renal creatinine clearance mechanism

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Predicting renal retention of radioconjugates in a human relevant in vitro model

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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model

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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSCs lines

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GFP immunofluorescence and brightfield images of RPE

Comprehensive toxicity study on retinal ganglion cells in early-stage human retinal organoids

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Development and characterisation of an early-stage retinal organoid disease model (for non-ocular disease)

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

Comprehensive in vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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Evaluation of glomerular ADC toxicity in podocytes

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Isolated primary podocytes immunostained for cilia

Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE

Predicting human renal injury from antisense oligonucleotide (ASO)

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