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Scientific Publications

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Application of organoid technology for retinal disease modelling and drug discovery

Application of organoid technology for retinal disease modelling & drug discovery

Valeria Chichagova. Drug Target Review. June 2020.

Newcells Biotech

c-Rel orchestrates energy-dependent epithelial & macrophage reprogramming in fibrosis

Nature Metabolism. 2020; 2:1350–1367

Posters

Utilization of high – content imaging for the study of lung fibrosis

High content imaging (HCI) assays enable the study of the fibrotic processes: fibroblast – to – myofibroblast transition (FMT) and epithelial – to – mesenchymal transition (EMT)

The aProximateTM model for renal drug safety/efficacy and transporter studies

Fact Sheets

iPSC-derived Retinal Organoids (RO)

High throughput, high sensitivity (HTHS) lung fibroblast-to-myofibroblasts transition (FMT) assay for anti-fibrotic drug screening

Press releases

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Scientific eBooks and Protocols

Lung models eBook

The front cover of the retinal organoid ebook

Retinal Organoids eBook

Q&A with our scientists

Dr Fiona Leslie

Meet the scientists: Dr Fiona Leslie, the scientist behind the development of the advanced FMT assay

Meet the scientists: Anusha Gupta, the scientist behind the development of the CBF assay

Dr Colin Brown face inside cells

The inside story of the development of Newcells’ MPS flow model: Scientific chat with Dr Colin Brown

Videos and Webinars

Creating a Powerful NAM respiratory Toxicology Strategy for Clinical Predictivity and IND success

Newcells Biotech – Kidney Model Capabilities

Meet Dr Kathryn Garner – Our Head of Kidney Development

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model

Evaluation of glomerular ADC toxicity in podocytes

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Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE