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Scientific Publications
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Significance of OAT2 and OCT2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells
Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown
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The chlorophenoxy herbicide MCPA: A mechanistic basis for the observed differences in toxicological profile in humans & rats vs dogs.
Alex Gledhill, Rachael Bowen, Michael Bartels, Andrew Bond, Git Chung, Colin D. A. Brown, Keith Pye & Tarang Vora
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Primary human proximal tubule cell monolayers as a predictive model of renal phosphate homeostasis in heath & disease
Colin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15
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The aProximateTM model for renal drug safety/efficacy and transporter studies
Development of photoreceptor outer segments in human iPSC derived retinal organoids produced at large scale
Developing predictive in vitro Glomerulus , Proximal Tubule and Loop of Henle renal cell model platforms to investigate the renal uptake and nephrotoxic liability of large molecules
White Papers
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Case Studies
View allAnalysis of the effect of a compound on retinal microtissue composition
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Development of a human in vitro model for retinitis pigmentosa
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Assessing the validity of a nephron model for a metabolic disease study
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DDI study on renal creatinine clearance mechanism
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Predicting renal retention of radioconjugates in a human relevant in vitro model
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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model
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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSC lines
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Comprehensive toxicity study on retinal ganglion cells in early-stage human retinal organoids
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Development and characterisation of an early-stage retinal organoid disease model (for non-ocular disease)
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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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Comprehensive in vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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