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Scientific Publications
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aProximate™ as a novel, predictive model of aminoglycoside-induced nephrotoxicity
Keith Pye, Git Chung, Lyle Armstrong, Mike Nicholds, Colin Brown Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS. Toxicol Lett. 2019;314:S167–8.
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Development of a novel predictive in vitro non human primate proximal tubule model for drug transporter & nephrotoxicity studies
Colin Brown Drug Metabolism and Pharmacokinetics. 2019; 34(1):S53
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In vitro platforms for de-risking nephrotoxicity during drug development
Dr Sandy Primrose & Dr Colin Brown Drug Target Review. March 2020
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Case Studies
View allQuantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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In vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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