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Primary human proximal tubule cell monolayers as a predictive model of renal phosphate homeostasis in heath & disease
Colin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15
Find out moreP52 – Determination of aminoglycoside toxicity in human renal proximal tubule monolayers using clinical relevant biomarkers of nephrotoxicity
Colin Brown, Lyle Armstrong, Mike Nicholds, Git Nicholds Drug Metabolism and Pharmacokinetics. 2020; 35(1):S37
Find out moreCharacterization of cisplatin toxicity in aProximate™ human proximal tubule cell monolayers
Colin Brown, Git Chung, Lyle Armstrong, Mike Nicholds Drug Metabolism and Pharmacokinetics. 2019; 34(1): S52-S53; SOT 2019 P105
Find out morePosters
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A Sensitive Nephrotoxicity Assay of in vitro Podocyte Effacement
A Live Cell High Content Imaging Assay for Monitoring Large Molecules Uptake into aProximateTM Proximal Tubule Epithelial Cells via Megalin and Cubulin
Development of highly-differentiated human primary proximal tubule MPS model (aProximate MPS™ Flow)
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Case Studies
View allQuantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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In vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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