Announcement:

We are delighted to announce the release of a new scientific publication in collaboration with the University of Newcastle on modelling Stargardt disease (STGD1) in vitro with retinal organoids (RO)!

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Resources

Scientific Publications

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Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

Colin D. A. Brown, Rachel Sayer, Amy S Windass, Iain S Haslam, Marc E De Broe, Patrick C D’Haese, Anja Verhulst Toxicology and Applied Pharmacology. 2008; 233(3): 428-438

Newcells Biotech

Primary human proximal tubule cell monolayers as a predictive model of renal phosphate homeostasis in heath & disease

Colin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15

Newcells Biotech

P52 – Determination of aminoglycoside toxicity in human renal proximal tubule monolayers using clinical relevant biomarkers of nephrotoxicity

Colin Brown, Lyle Armstrong, Mike Nicholds, Git Nicholds Drug Metabolism and Pharmacokinetics. 2020; 35(1):S37

Posters

A Sensitive Nephrotoxicity Assay of in vitro Podocyte Effacement

A Live Cell High Content Imaging Assay for Monitoring Large Molecules Uptake into aProximateTM Proximal Tubule Epithelial Cells via Megalin and Cubulin

Development of highly-differentiated human primary proximal tubule MPS model (aProximate MPS™ Flow)

Fact Sheets

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Press releases

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Scientific eBooks and Protocols

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Q&A with our scientists

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Videos and Webinars

Dr Kathryn Garner, PhD

Developing High Content Imaging Assays for Chronic Kidney Disease

Retinal Organoids as an Emerging Tool for Drug Discovery

Dr Colin Brown

The Kidney as a Therapeutic Target: Targeting Therapeutics to the Proximal Tubule

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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Evaluation of glomerular ADC toxicity in podocytes

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Isolated primary podocytes immunostained for cilia

Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE

Predicting human renal injury from antisense oligonucleotide (ASO)

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