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Scientific Publications
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Characterization of cisplatin toxicity in aProximate™ human proximal tubule cell monolayers
Colin Brown, Git Chung, Lyle Armstrong, Mike Nicholds Drug Metabolism and Pharmacokinetics. 2019; 34(1): S52-S53; SOT 2019 P105
Find out moreHuman primary proximal tubule cell monolayers as a novel predictive model of nephrotoxicity
Git Chung, Sarah Billington, R. D. Wilde, Colin Brown Toxicology Letters. 2016;258:S139-S140
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Application of organoid technology for retinal disease modelling & drug discovery
Valeria Chichagova. Drug Target Review. June 2020.
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Development of highly-differentiated human primary proximal tubule MPS model (aProximate MPS™ Flow)
The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of Antisense Oligonucleotide drug molecules
An in-vitro high-content imaging assay for the study of fibroblast activation and matrix deposition
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Case Studies
View allQuantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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In vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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