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Scientific Publications

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Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

Valeria Chichagova, Maria Georgiou, Madeleine Carter, Birthe Dorgau, Gerrit Hilgen, Joseph Collin, Rachel Queen, Git Chung, Jila Ajeian, Marina Moya-Molina, Stefan Kustermann, Francois Pognan, Philip Hewitt, Michael Schmitt, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako

water being sprayed on grass.

The chlorophenoxy herbicide MCPA: A mechanistic basis for the observed differences in toxicological profile in humans & rats vs dogs.

Alex Gledhill, Rachael Bowen, Michael Bartels, Andrew Bond, Git Chung, Colin D. A. Brown, Keith Pye & Tarang Vora

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

Michelle E. McClements, Hannah Steward, William Atkin, Emily Archer Goode, Carolina Gándara, Valeria Chichagova, and Robert E. MacLaren

Posters

Development of photoreceptor outer segments in human iPSC derived retinal organoids produced at large scale

Developing predictive in vitro Glomerulus , Proximal Tubule and Loop of Henle renal cell model platforms to investigate the renal uptake and nephrotoxic liability of large molecules

An in vitro model that predicts Antibiotic Renal Toxicity

Fact Sheets

The aProximateᵀᴹ Proximal tubule cells (PTC) model

Small airway epithelial cell (SAEC) model

High throughput, high sensitivity (HTHS) lung fibroblast-to-myofibroblasts transition (FMT) assay for anti-fibrotic drug screening

Press releases

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Scientific eBooks and Protocols

The front cover of the aproximate assay ready plates ebook

aProximate™ Assay-Ready Plates (Human, 24-well) User Guide

The front cover of the aProximate ebook

Renal Proximal Tubule Cells Model eBook

Q&A with our scientists

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Q&A with Dr Carolina Gandara, Head of retina assay development

Dr Megan Webster

The inside story of lung in vitro models with Dr Megan Webster

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Latest trends in Retinal Organoids: Scientific chat with Dr Valeria Chichagova

Videos and Webinars

Dr Mike Nicholds – How Newcells works with Clients

Creating a Powerful NAM respiratory Toxicology Strategy for Clinical Predictivity and IND success

Moving compounds to IND using predictive retina models

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model

Evaluation of glomerular ADC toxicity in podocytes

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Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE