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Scientific Publications
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aProximate™ as a novel, predictive model of aminoglycoside-induced nephrotoxicity
Keith Pye, Git Chung, Lyle Armstrong, Mike Nicholds, Colin Brown Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS. Toxicol Lett. 2019;314:S167–8.
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Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity
Piyush Bajaj, Git Chung, Keith Pye, Tomoya Yukawa, Akio Imanishi, Yuichi Takai, Colin Brown, Matthew P.Wagoner
Toxicology. 2020; 442:152535
Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling
Colin D. A. Brown, Rachel Sayer, Amy S Windass, Iain S Haslam, Marc E De Broe, Patrick C D’Haese, Anja Verhulst Toxicology and Applied Pharmacology. 2008; 233(3): 428-438
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Overcoming technical difficulties of in vitro assay – development
A Sensitive Nephrotoxicity Assay of in vitro Podocyte Effacement
A Live Cell High Content Imaging Assay for Monitoring Large Molecules Uptake into aProximateTM Proximal Tubule Epithelial Cells via Megalin and Cubulin
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Case Studies
View allAnalysis of the effect of a compound on retinal microtissue composition
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Development of a human in vitro model for retinitis pigmentosa
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Assessing the validity of a nephron model for a metabolic disease study
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DDI study on renal creatinine clearance mechanism
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Predicting renal retention of radioconjugates in a human relevant in vitro model
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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model
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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSCs lines
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Comprehensive toxicity study on retinal ganglion cells in early-stage human retinal organoids
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Development and characterisation of an early-stage retinal organoid disease model (for non-ocular disease)
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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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Comprehensive in vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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