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Primary human proximal tubule cell monolayers as a predictive model of renal phosphate homeostasis in heath & disease
Colin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15
Find out moreP52 – Determination of aminoglycoside toxicity in human renal proximal tubule monolayers using clinical relevant biomarkers of nephrotoxicity
Colin Brown, Lyle Armstrong, Mike Nicholds, Git Nicholds Drug Metabolism and Pharmacokinetics. 2020; 35(1):S37
Find out moreCharacterization of cisplatin toxicity in aProximate™ human proximal tubule cell monolayers
Colin Brown, Git Chung, Lyle Armstrong, Mike Nicholds Drug Metabolism and Pharmacokinetics. 2019; 34(1): S52-S53; SOT 2019 P105
Find out morePosters
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Development of highly-differentiated human primary proximal tubule MPS model (aProximate MPS™ Flow)
The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of Antisense Oligonucleotide drug molecules
An in-vitro high-content imaging assay for the study of fibroblast activation and matrix deposition
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Case Studies
View allAnalysis of the effect of a compound on retinal microtissue composition
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Development of a human in vitro model for retinitis pigmentosa
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Assessing the validity of a nephron model for a metabolic disease study
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DDI study on renal creatinine clearance mechanism
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Predicting renal retention of radioconjugates in a human relevant in vitro model
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Safety and efficacy evaluation of a novel therapeutic AAV vectors using a human retinal organoid model
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Comparing the transduction efficiency of two AAV vectors in RPE and Retinal Organoid models derived from iPSCs lines
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Comprehensive toxicity study on retinal ganglion cells in early-stage human retinal organoids
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Development and characterisation of an early-stage retinal organoid disease model (for non-ocular disease)
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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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Comprehensive in vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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Predicting human renal injury from antisense oligonucleotide (ASO)
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