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Resources

Scientific Publications

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water being sprayed on grass.

The chlorophenoxy herbicide MCPA: A mechanistic basis for the observed differences in toxicological profile in humans & rats vs dogs.

Alex Gledhill, Rachael Bowen, Michael Bartels, Andrew Bond, Git Chung, Colin D. A. Brown, Keith Pye & Tarang Vora

Cross species comparisons

aProximate™ as a novel, predictive model of aminoglycoside-induced nephrotoxicity

Keith Pye, Git Chung, Lyle Armstrong, Mike Nicholds, Colin Brown Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS. Toxicol Lett. 2019;314:S167–8.

Newcells Biotech

Review of pharmacokinetics & metabolism of triclopyr herbicide in mammals: Impact on safety assessments

Michael Bartels, Colin Brown, Git Chung, Melissa Chan, Claire Terry, Sean Gehen, Marco Corvaro Regulatory toxicology and pharmacology. 2020; 116:104714

Posters

A high-throughput, in vitro assessment of antibiotic induced podocyte injury

A Primary Human in vitro Focal Segmental Glomerulosclerosis (FSGS) model for drug development applications

An in vitro Human Primary Thick Ascending Limb Model For The Assessment of Compound Nephrotoxicity

Fact Sheets

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Press releases

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Scientific eBooks and Protocols

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Q&A with our scientists

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Videos and Webinars

Meet Dr Kathryn Garner – Our Head of Kidney Development

Newcells Biotech – Kidney Model Capabilities

Dr Mike Nicholds – About the company

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model

Evaluation of glomerular ADC toxicity in podocytes

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Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE