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Scientific Publications

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Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

Colin D. A. Brown, Rachel Sayer, Amy S Windass, Iain S Haslam, Marc E De Broe, Patrick C D’Haese, Anja Verhulst Toxicology and Applied Pharmacology. 2008; 233(3): 428-438

Newcells Biotech

Primary human proximal tubule cell monolayers as a predictive model of renal phosphate homeostasis in heath & disease

Colin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15

Newcells Biotech

P52 – Determination of aminoglycoside toxicity in human renal proximal tubule monolayers using clinical relevant biomarkers of nephrotoxicity

Colin Brown, Lyle Armstrong, Mike Nicholds, Git Nicholds Drug Metabolism and Pharmacokinetics. 2020; 35(1):S37

Posters

Development of highly-differentiated human primary proximal tubule MPS model (aProximate MPS™ Flow)

The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of Antisense Oligonucleotide drug molecules

Developing a Comprehensive Biomarker Package for Detecting Drug-Induced Injury in Podocytes

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Press releases

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Scientific eBooks and Protocols

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Q&A with our scientists

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Videos and Webinars

Reducing compound attrition by predicting renal tubular toxicity with in vitro PTEC models

Reducing compound attrition by predicting renal tubular toxicity with in vitro PTEC models

Improved phenotype of human proximal tubule epithelial cells in a 3D microfluidic model

Predictive in vitro primary proximal tubule models for understanding nephrotoxicity in drug development programs

Predictive in vitro primary proximal tubule models for understanding nephrotoxicity in drug development programs

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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Evaluation of glomerular ADC toxicity in podocytes

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Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE